| Name | Meaning | Gender | Origin |
|---|
| Sausage | Chopped meat stuffed into a prepared casing and cooked. | Unisex | English |
| Scamp | A mischievous youngster | Unisex | English |
| Schnapps | Variety of strong liquor usually associated with Holland | Unisex | English |
| Scooby | | Unisex | Hebrew |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Shredder | | Unisex | Hebrew |
| Skeeter | | Unisex | Hebrew |
| Skittles | | Unisex | Hebrew |
| Skunk | | Unisex | Hebrew |
| Sleepy | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smooches | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Sniff | A short inhale through the nose. To savour or investigate a smell. | Unisex | English |
| Sniffles | | Unisex | Hebrew |
| Snoopy | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Snowy | Covered with snow | Female | English |
| Snuffles | | Unisex | Hebrew |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Spanky | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Speckles | | Unisex | Hebrew |