| Name | Meaning | Gender | Origin |
|---|
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Soda | A carbonated water. | Unisex | English |
| Sophia | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spaz | For a spazy kitty | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Spring | To burst forth | Female | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Tango | | Unisex | Hebrew |
| Tasha | (Christ's) birthday | Female | Latin |
| Tess | Harvester | Female | Greek |
| Thunder | Stormy Tempered | Unisex | English |
| Tia | Princess Or Crowned One | Female | English |
| Tobey | God is good | Unisex | Hebrew |
| Toby | God is good | Unisex | Hebrew |
| Tootsie | A girl or young woman. | Unisex | English |
| Trooper | A state or mounted police officer. Also a member of a cavalry unit. | Unisex | English |
| Trudy | Strength of the spear | Female | Germanic |
| Twiggy | | Unisex | Hebrew |
| Vicki | Conqueror | Female | Latin |
| Whiskey | An alcoholic liquor distilled from grain | Unisex | English |
| Winnie | Blessed peace | Unisex | Welsh |
| Zoe | Life | Female | Greek |
| Zoey | Life | Female | Greek |