| Name | Meaning | Gender | Origin |
|---|
| Snowcone | | Unisex | Hebrew |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Solo | | Unisex | Hebrew |
| Sooty | Covered with soot | Unisex | English |
| Spam | | Unisex | Hebrew |
| Spanky | | Unisex | Hebrew |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spaz | For a spazy kitty | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spider | An eight legged insect | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Spud | Slang for potato. | Unisex | English |
| Squeak | | Unisex | Hebrew |
| Starfire | | Unisex | Hebrew |
| Stoner | Stone. | Unisex | English |
| Stormy | Violent weather | Unisex | English |
| Styx | Myth Name (A River Of The Underworld) | Unisex | English |
| Suede | Swedish | Unisex | English |
| Sunshine | Light from the sun | Unisex | English |
| Surf | | Unisex | Hebrew |
| Survivor | | Unisex | Hebrew |
| Taboo | | Unisex | Hebrew |
| Taco | A folded fried tortilla filled with meat, cheese and spices. | Unisex | English |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tarzan | White skin | Unisex | Literary |
| Taurus | Bull | Unisex | Latin |
| Taz | Wild Animal, Thrid Born | Unisex | American |