| Name | Meaning | Gender | Origin |
|---|
| Selena | Moon | Female | Greek |
| Semolina | | Unisex | Hebrew |
| Serena | Composed | Female | Latin |
| Seymour | Moor | Male | Latin |
| Shadow | Shadow | Unisex | English |
| Shaina | Beautiful | Female | Yiddish |
| Shakespeare | Brandish spear | Unisex | English |
| Shawnee | Tribal name | Female | Native American |
| Shea | Hawklike - graceful, free, courageous | Male | Gaelic |
| Shelby | A place where willows grow | Female | American English |
| Shilo | Gift for him | Unisex | Hebrew |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shona | God is gracious | Female | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Silas | Of the forest | Male | Latin |
| Silk | | Unisex | Hebrew |
| Sinclair | Saint Clair meaning holy light | Male | English |
| Skye | Cloud | Male | Norse |
| Skyler | Guarded | Unisex | Dutch |
| Slim | Slender in proportion to height. | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Socrates | Uncertain meaning | Male | Greek |
| Sofia | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Spencer | Someone who gives out goods | Male | French |
| Speranza | Hope | Female | Italian |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Splinter | | Unisex | Hebrew |