| Name | Meaning | Gender | Origin |
|---|
| Sally | Princess | Female | Hebrew |
| Sam | He is called god | Male | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sarah | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Scrappie | | Unisex | Hebrew |
| Seth | Appointed | Male | Hebrew |
| Shadow | Shadow | Unisex | English |
| Shannon | God is gracious | Female | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shona | God is gracious | Female | Hebrew |
| Simba | Lion | Female | Swahili |
| Smiley | | Unisex | Hebrew |
| Smoky | | Unisex | Hebrew |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Stanley | Meadow that is stony | Male | English |
| Star | Star | Female | Latin |
| Stella | Star | Female | Latin |
| Stitch | After the character in the Lilo And Stitch cartoon | Unisex | English |
| Storm | Violent weather | Female | English |