| Name | Meaning | Gender | Origin |
|---|
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Serena | Composed | Female | Latin |
| Shadow | Shadow | Unisex | English |
| Shasta | Name of a Native American tribe | Female | Native American |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shiva | Auspicious | Unisex | Sanskrit |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Sky | Sky | Unisex | Norse |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Sniper | A skilled shooter who spots targets from a concealed place. | Unisex | English |
| Snow | Snow, fair skinned | Female | English |
| Snowball | | Unisex | Hebrew |
| Snowy | Covered with snow | Female | English |
| Sonia | Wisdom | Female | Greek |
| Sonya | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Star | Star | Female | Latin |
| Stella | Star | Female | Latin |
| Storm | Violent weather | Female | English |
| Stormy | Violent weather | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suki | To like | Female | Japanese |
| Tahoe | Edge of the lake | Unisex | Native American |