| Name | Meaning | Gender | Origin |
|---|
| Sara | Princess | Female | Hebrew |
| Sarah | Princess | Female | Hebrew |
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Savannah | Plateau | Female | Spanish |
| Scarlett | Scarlet | Female | English |
| Scooby | | Unisex | Hebrew |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shady | | Unisex | Hebrew |
| Shaggy | Bushy and matted (hair), unkempt. | Unisex | English |
| Shasta | Name of a Native American tribe | Female | Native American |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shelly | Clearing near a ledge | Unisex | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Sienna | Reddish orange-brown | Female | Italian |
| Sierra | Mountain range | Female | Spanish |
| Silky | Soft as silk. | Unisex | English |
| Simba | Lion | Female | Swahili |
| Simone | Listening | Female | Hebrew |
| Sissy | Blind | Female | Latin |
| Skeeter | | Unisex | Hebrew |
| Skinny | | Unisex | Hebrew |
| Skippy | Master of a Ship | Unisex | American English |
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |