| Name | Meaning | Gender | Origin |
|---|
| Pumpkin | Large round fruit with orange skin | Unisex | English |
| Queenie | Female ruler | Female | English |
| Rascal | One that is playfully mischievous | Unisex | English |
| Ria | Bitter | Female | Hebrew |
| Rina | Pet form of names in -rina | Female | English |
| Ronnie | Ruler with counsel | Unisex | Norse |
| Rosa | Rose | Female | Latin |
| Rosie | Rose | Female | Latin |
| Roxy | Star | Female | Persian |
| Sable | Sable (black) | Unisex | English |
| Sadie | Princess | Female | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Savannah | Plateau | Female | Spanish |
| Selena | Moon | Female | Greek |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shelly | Clearing near a ledge | Unisex | English |
| Shorty | Of less than average size | Unisex | English |
| Silvana | Of the forest | Female | Latin |
| Simba | Lion | Female | Swahili |
| Slim | Slender in proportion to height. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Tiny | Extremely small | Unisex | English |