| Name | Meaning | Gender | Origin |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Sol | Peace | Male | Hebrew |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Spring | To burst forth | Female | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Sprout | | Unisex | Hebrew |
| Spud | Slang for potato. | Unisex | English |
| Stan | Meadow that is stony | Male | English |
| Star | Star | Female | Latin |
| Starr | Star | Female | Latin |
| Steve | Crown | Male | Greek |
| Stitch | After the character in the Lilo And Stitch cartoon | Unisex | English |
| Stone | Stone | Male | English |
| Storm | Violent weather | Female | English |
| Styx | Myth Name (A River Of The Underworld) | Unisex | English |
| Sue | Lily | Female | Hebrew |
| Sun | Goodness | Female | Korean |
| Sven | Boy, lad | Male | Norse |
| Swan | birds of the family Anatidae within the genus Cygnus | Both | English |
| Sweet | | Unisex | Hebrew |
| Switch | | Unisex | Hebrew |
| Tad | Poet | Male | Gaelic |
| Tai | Big | Unisex | Chinese |
| Tait | Cheerful | Unisex | Norse |
| Taj | Crown | Male | Sanskrit |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tate | "Pleasant And Bright."Some Variants Are Tait, Taite, And Tayte. | Female | English |
| Taz | Wild Animal, Thrid Born | Unisex | American |