| Name | Meaning | Gender | Origin |
|---|
| Simba | Lion | Female | Swahili |
| Sissy | Blind | Female | Latin |
| Slim | Slender in proportion to height. | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Starr | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suzie | Lily | Unisex | Hebrew |
| Sweetie | Sweetheart. | Unisex | English |
| Tallulah | Abundance, lady, princess | Female | Gaelic |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tasha | (Christ's) birthday | Female | Latin |
| Tess | Harvester | Female | Greek |
| Tia | Princess Or Crowned One | Female | English |
| Tiny | Extremely small | Unisex | English |
| Tito | Giant | Unisex | Latin |
| Toby | God is good | Unisex | Hebrew |
| Tootsie | A girl or young woman. | Unisex | English |
| Twiggy | | Unisex | Hebrew |
| Velvet | Soft | Female | English |
| Vicki | Conqueror | Female | Latin |
| Whitney | White island | Female | English |
| Winnie | Blessed peace | Unisex | Welsh |
| Zia | Splendor, light | Female | Arabic |
| Ziggy | Victory protection | Unisex | Germanic |
| Zoe | Life | Female | Greek |