| Name | Meaning | Gender | Origin |
|---|
| Sadie | Princess | Female | Hebrew |
| Sally | Princess | Female | Hebrew |
| Sam | He is called god | Male | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Saskia | Saxon woman | Female | Dutch |
| Sassy | Lively and spirited | Unisex | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sherman | One who shears cloth | Male | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Sissy | Blind | Female | Latin |
| Slim | Slender in proportion to height. | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squirt | Slang for a small person | Unisex | English |
| Starr | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suzie | Lily | Unisex | Hebrew |
| Sweetie | Sweetheart. | Unisex | English |