| Name | Meaning | Gender | Origin |
|---|
| Sadie | Princess | Female | Hebrew |
| Sally | Princess | Female | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Schnapps | Variety of strong liquor usually associated with Holland | Unisex | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Simba | Lion | Female | Swahili |
| Smoky | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Susie | Lily | Female | Hebrew |
| Tammy | Twin | Female | Aramaic |
| Tara | Crag | Female | Gaelic |
| Tasha | (Christ's) birthday | Female | Latin |
| Taylor | A tailor | Female | English |
| Tex | Of Texas | Unisex | English |
| Tinker | | Unisex | Hebrew |
| Toby | God is good | Unisex | Hebrew |
| Trigger | | Unisex | Hebrew |
| Trixie | Voyager through life | Female | Latin |
| Velma | Will, desire and helmet, protection | Female | Germanic |
| Vicki | Conqueror | Female | Latin |
| Zena | Life and zeus | Female | Polish |
| Zoe | Life | Female | Greek |