| Name | Meaning | Gender | Origin |
|---|
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Saxon | Sharp blade | Female | German |
| Scarlet | Scarlet | Female | English |
| Sebastian | Man from Sebaste | Male | Latin |
| Shark | | Unisex | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sienna | Reddish orange-brown | Female | Italian |
| Skipper | Master of a Ship | Male | American English |
| Sophie | Wisdom | Female | Greek |
| Steffi | Crown | Female | Greek |
| Strongheart | a male German Shepherd who became one of the earliest canine film stars | Both | English |
| Sundance | | Unisex | Hebrew |
| Sven | Boy, lad | Male | Norse |
| Taboo | | Unisex | Hebrew |
| Tai | Big | Unisex | Chinese |
| Talon | A claw | Male | English |
| Tango | | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tasha | (Christ's) birthday | Female | Latin |
| Tawny | Tawny, tanned | Female | English |
| Tempest | Storm | Female | English |