| Name | Meaning | Gender | Origin |
|---|
| Rocky | Battle cry | Male | Germanic |
| Romy | Sea dew | Unisex | Latin |
| Rosa | Rose | Female | Latin |
| Roscoe | Roe deer wood | Male | Norse |
| Rosie | Rose | Female | Latin |
| Rowdy | Boisterous. Western Nickname. | Unisex | English |
| Roxy | Star | Female | Persian |
| Rusty | Rusty, full of rust | Unisex | American English |
| Saber | Patient | Male | English |
| Sadie | Princess | Female | Hebrew |
| Sam | He is called god | Male | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sarah | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scout | Observer | Unisex | American English |
| Selena | Moon | Female | Greek |
| Seymour | Moor | Male | Latin |
| Shadow | Shadow | Unisex | English |
| Shawnee | Tribal name | Female | Native American |
| Shelby | A place where willows grow | Female | American English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Slim | Slender in proportion to height. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squirt | Slang for a small person | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |