| Name | Meaning | Gender | Origin |
|---|
| Shorty | Of less than average size | Unisex | English |
| Skeezix | | Unisex | Hebrew |
| Skippy | Master of a Ship | Unisex | American English |
| Skittles | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Sly | A forest | Unisex | Latin |
| Snickers | A brand of candy bar. | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Sparkey | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Spunky | Spirited, plucky. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Taco | A folded fried tortilla filled with meat, cheese and spices. | Unisex | English |
| Tahoe | Edge of the lake | Unisex | Native American |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tequila | An alcoholic liquor distilled from mescal. | Unisex | English |
| Tinker | | Unisex | Hebrew |
| Tiny | Extremely small | Unisex | English |
| Tito | Giant | Unisex | Latin |
| Toby | God is good | Unisex | Hebrew |
| Tootsie | A girl or young woman. | Unisex | English |
| Tuffy | | Unisex | Hebrew |
| Twiggy | | Unisex | Hebrew |
| Twix | Brand of chocolate bar. | Unisex | English |
| Volcom | | Unisex | Hebrew |
| Waffles | | Unisex | Hebrew |