| Name | Meaning | Gender | Origin |
|---|
| Selby | A place where willows grow | Female | American English |
| Sexy | | Unisex | Hebrew |
| Shadow | Shadow | Unisex | English |
| Shanice | God Is Gracious | Female | English |
| Sharon | The plains | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Skeezix | | Unisex | Hebrew |
| Skippy | Master of a Ship | Unisex | American English |
| Skittles | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Sly | A forest | Unisex | Latin |
| Snickers | A brand of candy bar. | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparkey | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Spunky | Spirited, plucky. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stella | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sweetie | Sweetheart. | Unisex | English |
| Sybil | Female prophet | Female | Greek |
| Sydney | Wide meadow | Female | English |
| Taco | A folded fried tortilla filled with meat, cheese and spices. | Unisex | English |
| Tahoe | Edge of the lake | Unisex | Native American |
| Talia | Dew of God | Female | Hebrew |