| Name | Meaning | Gender | Origin |
|---|
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scamp | A mischievous youngster | Unisex | English |
| Scar | From The Lion King | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Seiko | Sincere child | Unisex | Japanese |
| Shade | Sweetly singing | Unisex | African |
| Shadow | Shadow | Unisex | English |
| Shady | | Unisex | Hebrew |
| Shaq | Handsome | Unisex | Arabic |
| Silky | Soft as silk. | Unisex | English |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Sooty | Covered with soot | Unisex | English |
| Spade | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Spider | An eight legged insect | Unisex | English |
| Spooky | | Unisex | Hebrew |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Stormy | Violent weather | Unisex | English |
| Suede | Swedish | Unisex | English |
| Tex | Of Texas | Unisex | English |
| Thumper | To walk with heavy steps | Unisex | English |
| Thunder | Stormy Tempered | Unisex | English |
| Tiger | Tiger | Unisex | English |
| Tigger | From Winnie the Pooh | Unisex | English |
| Tike | | Unisex | Hebrew |
| Tiki | Maori figure representing an ancestor. A wooden or stone image of a Polynesian god. | Unisex | English |
| Tilly | Powerful battler | Unisex | Germanic |