| Name | Meaning | Gender | Origin |
|---|
| Sampson | Sun | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sancho | Saint. | Male | Latin |
| Sandy | Defending men | Male | Greek |
| Santo | Sacred | Male | Italian |
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sargent | A Squire | Male | English |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Sawyer | One who saws wood | Male | English |
| Scamp | A mischievous youngster | Unisex | English |
| Scar | From The Lion King | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Scully | Town Crier | Male | English |
| Seiko | Sincere child | Unisex | Japanese |
| Shade | Sweetly singing | Unisex | African |
| Shadow | Shadow | Unisex | English |
| Shady | | Unisex | Hebrew |
| Shaq | Handsome | Unisex | Arabic |
| Shyam | Black, dark | Male | Sanskrit |
| Silky | Soft as silk. | Unisex | English |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Sooty | Covered with soot | Unisex | English |
| Spade | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |