| Name | Meaning | Gender | Origin |
|---|
| Sara | Princess | Female | Hebrew |
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sargent | A Squire | Male | English |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Sauda | Dark and beautiful | Female | Swahili |
| Sawyer | One who saws wood | Male | English |
| Saxon | Sharp blade | Female | German |
| Scamp | A mischievous youngster | Unisex | English |
| Scar | From The Lion King | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Scully | Town Crier | Male | English |
| Seiko | Sincere child | Unisex | Japanese |
| Selena | Moon | Female | Greek |
| Selma | Helmet of God | Female | German |
| Shade | Sweetly singing | Unisex | African |
| Shadow | Shadow | Unisex | English |
| Shady | | Unisex | Hebrew |
| Shaq | Handsome | Unisex | Arabic |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shyam | Black, dark | Male | Sanskrit |
| Sierra | Mountain range | Female | Spanish |
| Silky | Soft as silk. | Unisex | English |
| Simba | Lion | Female | Swahili |