| Name | Meaning | Gender | Origin |
|---|
| Searlait | Tiny And Womanly | Female | English |
| Shanley | Old hero | Female | Gaelic |
| Shanna | Form of Shoshannah | Female | English |
| Shorty | Of less than average size | Unisex | English |
| Shysie | Silent Little One | Female | Native American |
| Sissy | Blind | Female | Latin |
| Skeeter | | Unisex | Hebrew |
| Skittles | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Smiley | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Snookums | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Solita | Alone | Female | Latin |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Spanky | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Squeaker | | Unisex | Hebrew |
| Squeakers | | Unisex | Hebrew |
| Squeaky | | Unisex | Hebrew |
| Squeek | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Stella | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suzie | Lily | Unisex | Hebrew |