| Name | Meaning | Gender | Origin |
|---|
| Sparkey | | Unisex | Hebrew |
| Sparkle | To shine with animation | Unisex | English |
| Sparrow | A bird | Female | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Sphinx | | Unisex | Hebrew |
| Spider | An eight legged insect | Unisex | English |
| Spinner | | Unisex | Hebrew |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Spooky | | Unisex | Hebrew |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Spunky | Spirited, plucky. | Unisex | English |
| Sputnik | | Unisex | Hebrew |
| Squeaky | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Star | Star | Female | Latin |
| Stardust | | Unisex | Hebrew |
| Starlight | | Unisex | Hebrew |
| Stella | Star | Female | Latin |
| Stinker | | Unisex | Hebrew |
| Stinky | | Unisex | Hebrew |
| Storm | Violent weather | Female | English |
| Stormy | Violent weather | Unisex | English |
| Stretch | To extend to full length. | Unisex | English |
| Stubby | | Unisex | Hebrew |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sundance | | Unisex | Hebrew |
| Sunshine | Light from the sun | Unisex | English |
| Sushi | Raw fish. | Unisex | English |