| Name | Meaning | Gender | Origin |
|---|
| Sammy | His name is God | Unisex | Hebrew |
| Sapphire | Beautiful jewel | Female | Greek |
| Sara | Princess | Female | Hebrew |
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassafras | | Unisex | Hebrew |
| Sassy | Lively and spirited | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Sausage | Chopped meat stuffed into a prepared casing and cooked. | Unisex | English |
| Savannah | Plateau | Female | Spanish |
| Scamper | | Unisex | Hebrew |
| Scarlet | Scarlet | Female | English |
| Schnapps | Variety of strong liquor usually associated with Holland | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scorpio | Scorpion | Unisex | English |
| Scotch | Scotch whiskey. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Serendipity | Chance | Unisex | English |
| Shadow | Shadow | Unisex | English |
| Shakespeare | Brandish spear | Unisex | English |
| Shamrock | | Unisex | Hebrew |
| Shania | Beautiful | Female | Yiddish |
| Shark | | Unisex | Hebrew |
| Sharona | The plains | Female | Hebrew |
| Shawnee | Tribal name | Female | Native American |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shiloh | Gift for him | Unisex | Hebrew |