| Name | Meaning | Gender | Origin |
|---|
| Shannon | God is gracious | Female | Hebrew |
| Shark | | Unisex | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sheridan | Long lived treasure | Unisex | Gaelic |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Sierra | Mountain range | Female | Spanish |
| Skylar | Guarded | Female | Dutch |
| Slim | Slender in proportion to height. | Unisex | English |
| Sly | A forest | Unisex | Latin |
| Snoop | To pry into the private affairs of others | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Spanky | | Unisex | Hebrew |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stella | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sweetie | Sweetheart. | Unisex | English |
| Taffy | Beloved | Female | Welsh |
| Tango | | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tara | Crag | Female | Gaelic |
| Tasha | (Christ's) birthday | Female | Latin |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Telly | Wise, Best | Unisex | Greek |
| Tempest | Storm | Female | English |