| Name | Meaning | Gender | Origin |
|---|
| Reba | To tie | Female | Hebrew |
| Rebecca | To tie | Female | Hebrew |
| Rebel | One that resists of defies authority | Unisex | English |
| Reno | Ruler with counsel | Unisex | Germanic |
| Rina | Pet form of names in -rina | Female | English |
| Rocket | To move swiftly and powerfully | Unisex | English |
| Rogue | | Unisex | Hebrew |
| Roman | Roman | Unisex | Latin |
| Romy | Sea dew | Unisex | Latin |
| Rosie | Rose | Female | Latin |
| Roxy | Star | Female | Persian |
| Ruby | Red | Female | Latin |
| Rusty | Rusty, full of rust | Unisex | American English |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Sage | Aromatic herb | Unisex | English |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shanley | Old hero | Female | Gaelic |