| Name | Meaning | Gender | Origin |
|---|
| Shelby | A place where willows grow | Female | American English |
| Sheridan | Long lived treasure | Unisex | Gaelic |
| Sherman | One who shears cloth | Male | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Sidney | Wide meadow | Male | English |
| Sierra | Mountain range | Female | Spanish |
| Skip | Master of a Ship | Male | American English |
| Skipper | Master of a Ship | Male | American English |
| Skylar | Guarded | Female | Dutch |
| Slevin | Mountain Man | Male | English |
| Slim | Slender in proportion to height. | Unisex | English |
| Sloan | Fighter | Male | American English |
| Sly | A forest | Unisex | Latin |
| Snoop | To pry into the private affairs of others | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sorley | Summer sailor | Male | Norse |
| Spanky | | Unisex | Hebrew |
| Spencer | Someone who gives out goods | Male | French |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stanley | Meadow that is stony | Male | English |
| Stefan | Crown | Male | Greek |
| Stella | Star | Female | Latin |
| Stew | Guardian of the house | Male | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sullivan | Keen eye | Male | Gaelic |