| Name | Meaning | Gender | Origin |
|---|
| Rusty | Rusty, full of rust | Unisex | American English |
| Ryan | Little King | Male | Gaelic |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Sage | Aromatic herb | Unisex | English |
| Sam | He is called god | Male | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Scully | Town Crier | Male | English |
| Seamus | Form Of James Supplanter. | Male | English |
| Shadow | Shadow | Unisex | English |
| Shamus | Supplanter | Male | Hebrew |
| Shanley | Old hero | Female | Gaelic |
| Shannon | God is gracious | Female | Hebrew |
| Shark | | Unisex | Hebrew |
| Shea | Hawklike - graceful, free, courageous | Male | Gaelic |
| Sheba | Daughter of an oath | Female | Hebrew |
| Sheehan | Little Peaceful One | Male | English |