| Name | Meaning | Gender | Origin |
|---|
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Sawyer | One who saws wood | Male | English |
| Scot | From Scotland: A Gael. Diminutive Of Scott. | Male | English |
| Seymour | Moor | Male | Latin |
| Shadow | Shadow | Unisex | English |
| Shamus | Supplanter | Male | Hebrew |
| Sheldon | Protected hill | Male | English |
| Sherlock | With cropped hair | Male | English |
| Sherwood | Bright, wooded glen | Male | English |
| Shorty | Of less than average size | Unisex | English |
| Slim | Slender in proportion to height. | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Solomon | Peace | Male | Hebrew |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stanley | Meadow that is stony | Male | English |
| Sterling | Little star - stellar | Male | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Sweetpea | | Unisex | Hebrew |
| Tanner | Tanner | Male | English |
| Taurus | Bull | Unisex | Latin |
| Teddy | Gift of God | Male | Greek |
| Thornton | Thorn bush enclosure or settlement | Male | English |
| Tigger | From Winnie the Pooh | Unisex | English |
| Tilly | Powerful battler | Unisex | Germanic |
| Tinker | | Unisex | Hebrew |