| Name | Meaning | Gender | Origin |
|---|
| Rain | Rain | Female | English |
| Rascal | One that is playfully mischievous | Unisex | English |
| Rayna | Queen | Female | Latin |
| Reba | To tie | Female | Hebrew |
| Rebecca | To tie | Female | Hebrew |
| Red | Red | Unisex | English |
| Rocket | To move swiftly and powerfully | Unisex | English |
| Rogue | | Unisex | Hebrew |
| Rosie | Rose | Female | Latin |
| Roxy | Star | Female | Persian |
| Rusty | Rusty, full of rust | Unisex | American English |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shasta | Name of a Native American tribe | Female | Native American |
| Shayla | Blind | Female | Latin |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Smoky | | Unisex | Hebrew |