| Name | Meaning | Gender | Origin |
|---|
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Scarlet | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Sebastian | Man from Sebaste | Male | Latin |
| Shadow | Shadow | Unisex | English |
| Shasta | Name of a Native American tribe | Female | Native American |
| Shayla | Blind | Female | Latin |
| Sheba | Daughter of an oath | Female | Hebrew |
| Sheila | Blind | Female | Latin |
| Shelby | A place where willows grow | Female | American English |
| Shilo | Gift for him | Unisex | Hebrew |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Sky | Sky | Unisex | Norse |
| Skylar | Guarded | Female | Dutch |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smokie | | Unisex | Hebrew |
| Smoky | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Snow | Snow, fair skinned | Female | English |
| Snowy | Covered with snow | Female | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Sooty | Covered with soot | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |