| Name | Meaning | Gender | Origin |
|---|
| Sacha | Protector of man | Male | Greek |
| Sadie | Princess | Female | Hebrew |
| Saffron | From the spice or the colour, yellow | Female | English |
| Sage | Aromatic herb | Unisex | English |
| Sally | Princess | Female | Hebrew |
| Sam | He is called god | Male | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Santos | Saints | Male | Spanish |
| Sara | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scout | Observer | Unisex | American English |
| Sebastian | Man from Sebaste | Male | Latin |
| September | From the month | Female | Latin |
| Shadow | Shadow | Unisex | English |
| Shamrock | | Unisex | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shorty | Of less than average size | Unisex | English |
| Sienna | Reddish orange-brown | Female | Italian |
| Simba | Lion | Female | Swahili |
| Slim | Slender in proportion to height. | Unisex | English |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |