| Name | Meaning | Gender | Origin |
|---|
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stanley | Meadow that is stony | Male | English |
| Sterling | Little star - stellar | Male | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sweet | | Unisex | Hebrew |
| Sweetie | Sweetheart. | Unisex | English |
| Sweetpea | | Unisex | Hebrew |
| Sylvester | A forest | Male | Latin |
| Tanner | Tanner | Male | English |
| Tasha | (Christ's) birthday | Female | Latin |
| Taylor | A tailor | Female | English |
| Ted | Gift of God | Male | Greek |
| Teddy | Gift of God | Male | Greek |
| Tess | Harvester | Female | Greek |
| Tia | Princess Or Crowned One | Female | English |
| Tigger | From Winnie the Pooh | Unisex | English |
| Tilly | Powerful battler | Unisex | Germanic |
| Tinker | | Unisex | Hebrew |
| Tiny | Extremely small | Unisex | English |
| Toby | God is good | Unisex | Hebrew |
| Toffee | A hard brown, chewy candy | Unisex | English |
| Tootsie | A girl or young woman. | Unisex | English |
| Tristan | Tumult | Male | Gaelic |
| Tucker | Someone who folds cloth | Male | English |
| Twiggy | | Unisex | Hebrew |