| Name | Meaning | Gender | Origin |
|---|
| Pipsqueak | | Unisex | Hebrew |
| Pixel | | Unisex | Hebrew |
| Pixie | A fairy like creature. Playful and mischievous | Female | English |
| Poco | Little. | Unisex | English |
| Popcorn | Corn that when heated forms white edible puffs. | Unisex | English |
| Posy | He will enlarge | Female | Hebrew |
| Precious | Loved | Female | English |
| Pumpkin | Large round fruit with orange skin | Unisex | English |
| Queenie | Female ruler | Female | English |
| Quimby | From the woman's estate | Unisex | English |
| Raisin | | Unisex | Hebrew |
| Rascal | One that is playfully mischievous | Unisex | English |
| Rosa | Rose | Female | Latin |
| Ruby | Red | Female | Latin |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Scooby | | Unisex | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Skeeter | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Smiley | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Snookums | | Unisex | Hebrew |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Spanky | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Squeakers | | Unisex | Hebrew |
| Squeaky | | Unisex | Hebrew |