| Name | Meaning | Gender | Origin |
|---|
| Rusty | Rusty, full of rust | Unisex | American English |
| Ryan | Little King | Male | Gaelic |
| Rylee | Rye clearing | Unisex | English |
| Saber | Patient | Male | English |
| Sage | Aromatic herb | Unisex | English |
| Sam | He is called god | Male | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sanders | Defending men | Male | Greek |
| Sandy | Defending men | Male | Greek |
| Sani | Saturn | Male | Indian |
| Sascha | Defending men | Unisex | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scully | Town Crier | Male | English |
| Seamus | Form Of James Supplanter. | Male | English |
| Sebastian | Man from Sebaste | Male | Latin |
| Semolina | | Unisex | Hebrew |
| Shaggy | Bushy and matted (hair), unkempt. | Unisex | English |
| Shamrock | | Unisex | Hebrew |
| Shea | Hawklike - graceful, free, courageous | Male | Gaelic |
| Shelly | Clearing near a ledge | Unisex | English |
| Sherman | One who shears cloth | Male | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Sidney | Wide meadow | Male | English |
| Silk | | Unisex | Hebrew |
| Simon | Listening | Male | Hebrew |
| Skye | Cloud | Male | Norse |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Spanky | | Unisex | Hebrew |