| Name | Meaning | Gender | Origin |
|---|
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Scratch | | Unisex | Hebrew |
| Seth | Appointed | Male | Hebrew |
| Shadow | Shadow | Unisex | English |
| Shepherd | One who guards sheeps | Male | English |
| Sherman | One who shears cloth | Male | English |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snake | | Unisex | Hebrew |
| Snap | | Unisex | Hebrew |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spunky | Spirited, plucky. | Unisex | English |
| Stewie | | Unisex | Hebrew |
| Sylvester | A forest | Male | Latin |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tarzan | White skin | Unisex | Literary |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| T-bone | A thick steak containing a T shaped bone. | Unisex | English |
| Terminator | | Unisex | Hebrew |
| Thor | Thunder | Male | Norse |
| Thunder | Stormy Tempered | Unisex | English |
| Tiger | Tiger | Unisex | English |
| Titan | Powerful big man | Unisex | Greek |
| Tito | Giant | Unisex | Latin |
| Trooper | A state or mounted police officer. Also a member of a cavalry unit. | Unisex | English |
| Tsunami | Tidal wave | Unisex | English |
| Tuff | Fun spelling of tough; strong and resilient. | Unisex | English |
| Tuffy | | Unisex | Hebrew |
| Tyson | Son of Dye | Male | English |