| Name | Meaning | Gender | Origin |
|---|
| Shysie | Silent Little One | Female | Native American |
| Sissy | Blind | Female | Latin |
| Skeeter | | Unisex | Hebrew |
| Skittles | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Smiley | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Snookums | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Solita | Alone | Female | Latin |
| Sophie | Wisdom | Female | Greek |
| Spanky | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Squeakers | | Unisex | Hebrew |
| Squeaky | | Unisex | Hebrew |
| Squeek | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Stella | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suzie | Lily | Unisex | Hebrew |
| Taffy | Beloved | Female | Welsh |
| Talitha | Little girl | Female | Aramaic |
| Tawnie | A Green Field: The Warm Sandy Color Of A Lion's Coat. | Female | English |
| Teagan | Little poet | Female | Gaelic |
| Teeny | | Unisex | Hebrew |
| Tiger | Tiger | Unisex | English |
| Tink | | Unisex | Hebrew |