| Name | Meaning | Gender | Origin |
|---|
| River | River | Unisex | English |
| Rocky | Battle cry | Male | Germanic |
| Rose | Rose | Female | Latin |
| Rosie | Rose | Female | Latin |
| Roxy | Star | Female | Persian |
| Sable | Sable (black) | Unisex | English |
| Sadie | Princess | Female | Hebrew |
| Sage | Aromatic herb | Unisex | English |
| Sam | He is called god | Male | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scarlett | Scarlet | Female | English |
| Seven | Seven | Unisex | American English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shepherd | One who guards sheeps | Male | English |
| Shorty | Of less than average size | Unisex | English |
| Silk | | Unisex | Hebrew |
| Silver | Silver (the metal or colour) | Male | English |
| Simba | Lion | Female | Swahili |
| Sky | Sky | Unisex | Norse |
| Slim | Slender in proportion to height. | Unisex | English |
| Small | | Unisex | Hebrew |
| Snickers | A brand of candy bar. | Unisex | English |
| Snow | Snow, fair skinned | Female | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |