| Name | Meaning | Gender | Origin |
|---|
| Rogue | | Unisex | Hebrew |
| Romy | Sea dew | Unisex | Latin |
| Rose | Rose | Female | Latin |
| Roxy | Star | Female | Persian |
| Ruby | Red | Female | Latin |
| Rufus | Red | Male | Latin |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Saffron | From the spice or the colour, yellow | Female | English |
| Samantha | Listener | Female | Aramaic |
| Sandy | Defending men | Male | Greek |
| Sashi | Moonbeam | Female | Hindu |
| Saskia | Saxon woman | Female | Dutch |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Scarlet | Scarlet | Female | English |
| Sebastian | Man from Sebaste | Male | Latin |
| Selina | Moon | Female | Greek |
| Shelby | A place where willows grow | Female | American English |
| Shelley | Clearing near a ledge | Male | English |
| Sherman | One who shears cloth | Male | English |
| Sierra | Mountain range | Female | Spanish |
| Silvana | Of the forest | Female | Latin |
| Sooty | Covered with soot | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Suzy | Lily | Female | Hebrew |
| Tabitha | Gazelle | Female | Aramaic |