| Name | Meaning | Gender | Origin |
|---|
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Shadow | Shadow | Unisex | English |
| Shan | God is gracious | Unisex | Hebrew |
| Shelly | Clearing near a ledge | Unisex | English |
| Shorty | Of less than average size | Unisex | English |
| Simpson | Listening | Unisex | Hebrew |
| Sleepy | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Sprout | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |
| Suede | Swedish | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Tango | | Unisex | Hebrew |
| T-bone | A thick steak containing a T shaped bone. | Unisex | English |
| Tex | Of Texas | Unisex | English |
| Toby | God is good | Unisex | Hebrew |
| Tootsie | A girl or young woman. | Unisex | English |
| Tory | Conqueror | Unisex | Latin |
| Twiggy | | Unisex | Hebrew |
| Wrangler | | Unisex | Hebrew |
| Zanzibar | | Unisex | Hebrew |
| Ziggy | Victory protection | Unisex | Germanic |
| Zipper | | Unisex | Hebrew |