| Name | Meaning | Gender | Origin |
|---|
| Sara | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Satsuki | Fifth month | Unisex | Japanese |
| Scarlet | Scarlet | Female | English |
| Scooby | | Unisex | Hebrew |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Shadow | Shadow | Unisex | English |
| Shan | God is gracious | Unisex | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shelly | Clearing near a ledge | Unisex | English |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Simpson | Listening | Unisex | Hebrew |
| Sleepy | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Sprout | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Star | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Suede | Swedish | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sweetie | Sweetheart. | Unisex | English |