| Name | Meaning | Gender | Origin |
|---|
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shelly | Clearing near a ledge | Unisex | English |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Simon | Listening | Male | Hebrew |
| Simpson | Listening | Unisex | Hebrew |
| Skye | Cloud | Male | Norse |
| Sleepy | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Sol | Peace | Male | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Sprout | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Stanley | Meadow that is stony | Male | English |
| Star | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Suede | Swedish | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sunny | Filled with sunlight | Male | English |
| Sweetie | Sweetheart. | Unisex | English |
| Tabitha | Gazelle | Female | Aramaic |
| Taffy | Beloved | Female | Welsh |
| Tango | | Unisex | Hebrew |