| Name | Meaning | Gender | Origin |
|---|
| Sadie | Princess | Female | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Skylar | Guarded | Female | Dutch |
| Smiley | | Unisex | Hebrew |
| Smoky | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Snowy | Covered with snow | Female | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Stormy | Violent weather | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Tacoma | | Unisex | Hebrew |
| Tasha | (Christ's) birthday | Female | Latin |
| Tip | From Thomas, Meaning Twin | Unisex | Greek |
| Titan | Powerful big man | Unisex | Greek |
| Toby | God is good | Unisex | Hebrew |
| Tori | Conqueror | Female | Latin |
| Trinity | Threefold | Female | Latin |
| Uno | | Unisex | Hebrew |
| Vanilla | Flavouring agent from the vanilla bean | Unisex | English |