| Name | Meaning | Gender | Origin |
|---|
| Sachi | Colorful wisdom | Female | Japanese |
| Safari | | Unisex | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sampson | Sun | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scar | From The Lion King | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Selena | Moon | Female | Greek |
| Shark | | Unisex | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sherman | One who shears cloth | Male | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Sienna | Reddish orange-brown | Female | Italian |
| Simba | Lion | Female | Swahili |
| Simone | Listening | Female | Hebrew |
| Spartacus | From the city of Sparta | Unisex | English |
| Steve | Crown | Male | Greek |
| Talon | A claw | Male | English |
| Tamara | Palm tree | Female | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tasha | (Christ's) birthday | Female | Latin |