| Name | Meaning | Gender | Origin |
|---|
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Slate | | Unisex | Hebrew |
| Sly | A forest | Unisex | Latin |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smores | | Unisex | Hebrew |
| Snap | | Unisex | Hebrew |
| Sneezy | | Unisex | Hebrew |
| Snickers | A brand of candy bar. | Unisex | English |
| Sniffles | | Unisex | Hebrew |
| Snookums | | Unisex | Hebrew |
| Snoopy | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Snuffles | | Unisex | Hebrew |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Solo | | Unisex | Hebrew |
| Spam | | Unisex | Hebrew |
| Spanky | | Unisex | Hebrew |
| Sparkey | | Unisex | Hebrew |
| Sparkle | To shine with animation | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Sphinx | | Unisex | Hebrew |
| Spider | An eight legged insect | Unisex | English |
| Spinner | | Unisex | Hebrew |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Spooky | | Unisex | Hebrew |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |