| Name | Meaning | Gender | Origin |
|---|
| Sly | A forest | Unisex | Latin |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smores | | Unisex | Hebrew |
| Snap | | Unisex | Hebrew |
| Sneezy | | Unisex | Hebrew |
| Snickers | A brand of candy bar. | Unisex | English |
| Sniffles | | Unisex | Hebrew |
| Snookums | | Unisex | Hebrew |
| Snoopy | | Unisex | Hebrew |
| Snow | Snow, fair skinned | Female | English |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Snuffles | | Unisex | Hebrew |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Socrates | Uncertain meaning | Male | Greek |
| Soleil | Sun | Female | French |
| Solo | | Unisex | Hebrew |
| Solomon | Peace | Male | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Spam | | Unisex | Hebrew |
| Spanky | | Unisex | Hebrew |
| Sparkey | | Unisex | Hebrew |
| Sparkle | To shine with animation | Unisex | English |
| Sparrow | A bird | Female | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Sphinx | | Unisex | Hebrew |
| Spider | An eight legged insect | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spinner | | Unisex | Hebrew |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |