| Name | Meaning | Gender | Origin |
|---|
| Rusty | Rusty, full of rust | Unisex | American English |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sara | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Serafina | From seraphim, meaning fiery ones | Female | Latin |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Smoky | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Stefania | Crown | Female | Greek |
| Storm | Violent weather | Female | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sun | Goodness | Female | Korean |
| Taryn | King Of Rocky Hill. Variant Of Tarynn. | Female | American English |
| Tasha | (Christ's) birthday | Female | Latin |
| Tekla | God + Glory | Female | Greek |