| Name | Meaning | Gender | Origin |
|---|
| Pluto | Wealth, riches | Unisex | Greek |
| Puma | | Unisex | Hebrew |
| Queen | Female ruler | Unisex | English |
| Rambo | | Unisex | Hebrew |
| Rebel | One that resists of defies authority | Unisex | English |
| Rhino | | Unisex | Hebrew |
| River | River | Unisex | English |
| Rogue | | Unisex | Hebrew |
| Roman | Roman | Unisex | Latin |
| Rowdy | Boisterous. Western Nickname. | Unisex | English |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Schnapps | Variety of strong liquor usually associated with Holland | Unisex | English |
| Scout | Observer | Unisex | American English |
| Shade | Sweetly singing | Unisex | African |
| Shadow | Shadow | Unisex | English |
| Shark | | Unisex | Hebrew |
| Shilo | Gift for him | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Smoky | | Unisex | Hebrew |
| Sniper | A skilled shooter who spots targets from a concealed place. | Unisex | English |
| Snuffleupagus | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Spartacus | From the city of Sparta | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Suede | Swedish | Unisex | English |