| Name | Meaning | Gender | Origin |
|---|
| Serge | Servant | Male | Latin |
| Shade | Sweetly singing | Unisex | African |
| Shadow | Shadow | Unisex | English |
| Shark | | Unisex | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Sherlock | With cropped hair | Male | English |
| Shilo | Gift for him | Unisex | Hebrew |
| Simba | Lion | Female | Swahili |
| Sky | Sky | Unisex | Norse |
| Smoky | | Unisex | Hebrew |
| Sniper | A skilled shooter who spots targets from a concealed place. | Unisex | English |
| Snuffleupagus | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spartacus | From the city of Sparta | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Stetson | Son of Stephen | Male | English |
| Suede | Swedish | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sundance | | Unisex | Hebrew |
| Tango | | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Taro | Plump son | Male | Japanese |
| Tasha | (Christ's) birthday | Female | Latin |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| T-bone | A thick steak containing a T shaped bone. | Unisex | English |
| Teddy | Gift of God | Male | Greek |
| Tequila | An alcoholic liquor distilled from mescal. | Unisex | English |