| Name | Meaning | Gender | Origin |
|---|
| Rina | Pet form of names in -rina | Female | English |
| Rio | River | Male | Spanish |
| Robin | Bright fame | Female | Germanic |
| Rocky | Battle cry | Male | Germanic |
| Rosie | Rose | Female | Latin |
| Roxy | Star | Female | Persian |
| Sadie | Princess | Female | Hebrew |
| Sam | He is called god | Male | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scamp | A mischievous youngster | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Skipper | Master of a Ship | Male | American English |
| Slim | Slender in proportion to height. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stella | Star | Female | Latin |
| Stitch | After the character in the Lilo And Stitch cartoon | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sweetie | Sweetheart. | Unisex | English |
| Teddy | Gift of God | Male | Greek |
| Tiny | Extremely small | Unisex | English |
| Toby | God is good | Unisex | Hebrew |