| Name | Meaning | Gender | Origin |
|---|
| Scott | Painted warrior | Male | English |
| Scotty | Painted warrior | Male | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shaggy | Bushy and matted (hair), unkempt. | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Simba | Lion | Female | Swahili |
| Skippy | Master of a Ship | Unisex | American English |
| Smoky | | Unisex | Hebrew |
| Sniff | A short inhale through the nose. To savour or investigate a smell. | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Star | Star | Female | Latin |
| Starlight | | Unisex | Hebrew |
| Stevie | Crown | Unisex | Greek |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suki | To like | Female | Japanese |
| Sunny | Filled with sunlight | Male | English |
| Suzy | Lily | Female | Hebrew |
| Sylvester | A forest | Male | Latin |
| Taffy | Beloved | Female | Welsh |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tasha | (Christ's) birthday | Female | Latin |
| T-bone | A thick steak containing a T shaped bone. | Unisex | English |
| Ted | Gift of God | Male | Greek |
| Teddy | Gift of God | Male | Greek |