| Name | Meaning | Gender | Origin |
|---|
| Santiago | Saint James | Male | Spanish |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scott | Painted warrior | Male | English |
| Scout | Observer | Unisex | American English |
| Sebastian | Man from Sebaste | Male | Latin |
| Seth | Appointed | Male | Hebrew |
| Seymour | Moor | Male | Latin |
| Sheldon | Protected hill | Male | English |
| Shelly | Clearing near a ledge | Unisex | English |
| Sherlock | With cropped hair | Male | English |
| Sherman | One who shears cloth | Male | English |
| Sherwood | Bright, wooded glen | Male | English |
| Simon | Listening | Male | Hebrew |
| Skippy | Master of a Ship | Unisex | American English |
| Smaug | | Unisex | Hebrew |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Sputnik | | Unisex | Hebrew |
| Stephan | Crown | Male | Greek |
| Steve | Crown | Male | Greek |
| Steven | Crown | Male | Greek |
| Stewart | Guardian of the house | Male | English |
| Stewie | | Unisex | Hebrew |
| Stuart | Gaurdian of the House | Male | English |
| Teddy | Gift of God | Male | Greek |
| Thaddeus | Uncertain, perhaps praised or heart | Male | Aramaic |
| Theo | Gift of God | Male | Greek |